Description
Product Characteristics:
Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.
Synonyms: NFAT5 phospho S1197, p-NFAT5phospho S1197, Glutamine rich protein H65, KIAA0827, NF AT5, NF-AT5, NFAT 5, NFAT L1, NFAT like protein 1, NFAT5, NFAT5_HUMAN, NFATL 1, NFATL1, NFATZ, Nuclear factor of activated T cells 5, Nuclear factor of activated T cells 5 tonicity responsive, Nuclear factor of activated T cells, Nuclear factor of activated T-cells 5, OREBP, Osmotic response element binding protein, T cell transcription factor NFAT 5, T cell transcription factor NFAT5, T-cell transcription factor NFAT5, TonE binding protein, TonE-binding protein, TonEBP, Tonicity responsive enhancer binding protein, Tonicity-responsive enhancer-binding protein.
Target Information: The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]